Immunohistochemical Study on Hepatic Component Cells and Extracellular Matrix in Wistar Rats with Galactosamine-induced Acute Hepatitis

Abstract

After a single administration of D-galactosamine hydrochloride (GalN) in Wistar rats, hepatocyte apoptosis was followed by proliferation of oval cells, resulting in formation of small bile duct-like structures. An activation of Ito cells seems to participate in the formation of small bile duct-like structures through the production of laminin and fibronectin which are primary components of basement membrane.