Cartilage-forming Tumors at Multiple Sites in Two B6C3F1 Mice

Masayo Hosoi; Kazushige Hasegawa; Tohru Kihara; Rumiko Miyajima; Shinji Yamamoto; Shin-ichi Mikami; Seiki Yamakawa; Hijiri Iwata; Yasuhiko Hirouchi; Makoto Enomoto

doi:10.1293/tox.13.131

Case Reports

Cartilage-forming Tumors at Multiple Sites in Two B6C3F₁ Mice

Masayo Hosoi, Kazushige Hasegawa, Tohru Kihara, Rumiko Miyajima, Shinji Yamamoto, Shin-ichi Mikami, Seiki Yamakawa, Hijiri Iwata, Yasuhiko Hirouchi, Makoto Enomoto

Author information

Masayo Hosoi
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Kazushige Hasegawa
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Tohru Kihara
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Rumiko Miyajima
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Shinji Yamamoto
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Shin-ichi Mikami
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Seiki Yamakawa
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Hijiri Iwata
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Yasuhiko Hirouchi
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan
Makoto Enomoto
Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama, Shioshinden, Fukude-cho, Iwata-gun, Shizuoka, 437-1213, Japan

Keywords: Chondroma, Chondrosarcoma, Rib, Vertebrae, B6C3F₁ mouse

JOURNAL FREE ACCESS

2000 Volume 13 Issue 2 Pages 131-134

DOI https://doi.org/10.1293/tox.13.131

Details

Abstract

Multiple chondromas were observed in one young adult (18 weeks old) male B6C3F₁ strain mouse used in toxicity tests for safety assessment of chemicals. Solitary chondroma composed of mature cartilage cells was found in different sites of the ribs. In addition, chondrosarcoma was observed in the lumbar vertebra and abdominal cavity of one old (109 weeks old) male mouse of the same strain. The sarcoma was composed of mixed atypical chondrocytic and spindle-shaped cells, extending into the surrounding tissue. This is a report on spontaneous multiple chondromas occurring in the B6C3F₁ mouse.

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