Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Proceedings for Symposium “Toxic Changes of Endocrine Organs and Endocrine Disrupting Chemical” in the XVI Meeting of Japanese Society of Toxicologic Pathology
Endocrine System and Endocrine Disrupting Chemicals (EDCs)
R. Yoshiyuki OsamuraToshiki IwasakaShinobu Umemura
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2001 Volume 14 Issue 1 Pages 59

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Abstract
Recently, much has been focused on the potential for a wide range of chemicals to interact with the disruption of the endocrine system in humans and animals. Some of those chemicals have been implicated as endocrine disrupting chemicals (EDCs). We represent this review that the current endocrine systems including of molecular biology and effects of EDCs are discussed, as examples pituitary and mammary gland. Alterations to the endocrine environment caused by EDCs may occur through interference with the synthesis, secretion, transport, binding, action, or elimination of natural hormones responsible for vital homeostasis, differentiation, development, reproduction, and/or behavior. It is important consideration for assessing the adverse effects of EDCs to have an understanding of normal endocrine systems, subsequently, dose, duration of exposure, age, sex, situation, and frequency are estimated.
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© 2001 The Japanese Society of Toxicologic Pathology
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