Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Short Communication
Suppression of Cholangiocarcinoma Development by Aminoguanidine in the Liver Fluke-infested Hamster
Ki-Taek NamDae-Yong KimMi-Sun ParkDong-Deuk JangKi-Hwa YangJeong-Hee HanByung-Il Yoon
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JOURNAL FREE ACCESS

2005 Volume 18 Issue 1 Pages 65-68

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Abstract
Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted.
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© 2005 The Japanese Society of Toxicologic Pathology
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