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Journal of Toxicologic Pathology
Vol. 18 (2005) No. 1 P 65-68



Short Communication

Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted.

Copyright © 2005 The Japanese Society of Toxicologic Pathology

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