Ameloblastic Odontoma with Amyloid Deposition in a Mouse

Abstract

A female BALB/c:Slc mouse was administered two intravenous injections of doxorubicin (5 mg/kg) at the ages of 22 and 24 weeks. When this mouse was sacrificed at the age of 30 weeks, a tumor was found in the left mandible. The tumor was composed of dental tissues at varying stages of differentiation, ranging from primitive tooth germ-like structures to mature tooth-like tissue. Amyloid deposition was noted in a part of the tumor. Based on these histopathological findings, the tumor was diagnosed as an ameloblastic odontoma with amyloid deposition.