Corneal Mineralization in Wistar Hannover Rats

Satomi HASHIMOTO; Takuya DOI; Yumi WAKO; Junko SATO; Sou WADA; Minoru TSUCHITANI

doi:10.1293/tox.26.275

Original Articles

Corneal Mineralization in Wistar Hannover Rats

Satomi HASHIMOTO, Takuya DOI, Yumi WAKO, Junko SATO, Sou WADA, Minoru TSUCHITANI

Author information

Satomi HASHIMOTO
Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan
Takuya DOI
Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan
Yumi WAKO
Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan
Junko SATO
Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan
Sou WADA
Safety Assessment Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan
Minoru TSUCHITANI
Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

Keywords: Wistar Hannover rat, Background data, Cornea, Mineralization, Keratocyte

JOURNAL FREE ACCESS

2013 Volume 26 Issue 3 Pages 275-281

DOI https://doi.org/10.1293/tox.26.275

Details

Abstract

We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan^TM:WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa’s method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance.

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