Similarity of GATA-3 Expression between Rat and Human Mammary Glands

Yuichi Kinoshita; Katsuhiko Yoshizawa; Yuko Emoto; Michiko Yuki; Takashi Yuri; Nobuaki Shikata; Airo Tsubura

doi:10.1293/tox.2014-0008

Short Communications

Similarity of GATA-3 Expression between Rat and Human Mammary Glands

Yuichi Kinoshita, Katsuhiko Yoshizawa, Yuko Emoto, Michiko Yuki, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

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Yuichi Kinoshita
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan
Katsuhiko Yoshizawa
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
Yuko Emoto
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
Michiko Yuki
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
Takashi Yuri
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
Nobuaki Shikata
Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan
Airo Tsubura
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan

Keywords: GATA-3, immunohistochemistry, mammary gland, mammary tumor, rats

JOURNAL FREE ACCESS

2014 Volume 27 Issue 2 Pages 159-162

DOI https://doi.org/10.1293/tox.2014-0008

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Abstract

The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans.

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