Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
Case Report
Autopsy report for a caffeine intoxication case and review of the current literature
Takuma YamamotoKatsuhiko YoshizawaShin-ichi KuboYuko EmotoKenji HaraBrian WatersTakahiro UmeharaTakehiko MuraseKazuya Ikematsu
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2015 Volume 28 Issue 1 Pages 33-36


Caffeine (1,3,7-trimethylxanthine) is a popular mild central nervous system stimulant found in the leaves, seeds and fruits of various plants and in foodstuffs such as coffee, tea, and chocolate, among others. Caffeine is widely used and is not associated with severe side effects when consumed at relatively low doses. Although rarely observed, overdoses can occur. However, only a few fatal caffeine intoxication cases have been reported in the literature. Herein, we report the pathological examination results and information on caffeine concentrations in the blood, urine and main organs in a fatal caffeine intoxication case. Even though high caffeine concentrations were found in the systemic organs, no caffeine-related pathological changes were detected.

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© 2015 The Japanese Society of Toxicologic Pathology
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