Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Case Report
Adenocarcinoma of Barrett’s esophagus in a dog
James K. ChambersTsubasa SaitoKenjiro FukushimaShigeru KakutaJun NakayamaKoichi OhnoHajime TsujimotoHiroyuki NakayamaKazuyuki Uchida
Author information
JOURNAL FREE ACCESS

2017 Volume 30 Issue 3 Pages 239-243

Details
Abstract

An endoscopic examination revealed a mass in the distal esophagus of a 9-year-old intact male bulldog. Histopathologically, the mass was composed of cuboidal to columnar neoplastic epithelial cells and extended from the squamous epithelium of the esophageal mucosa, indicating that the tumor was derived from Barrett’s esophagus. Moreover, highly atypical foci that exhibited a cribriform pattern and high mitotic indices were also observed. The epithelial cells on the surface of the lesion often produced mucus that was positive for Alcian blue and immunohistochemically positive for MUC5AC. The neoplastic epithelial cells were diffusely positive for cytokeratin 7 and p53, and occasionally positive for cytokeratin 20. Based on these findings, the tumor was diagnosed as an adenocarcinoma. This report describes the clinical and pathological features of a spontaneous case of adenocarcinoma of Barrett’s esophagus in a dog.

Content from these authors
© 2017 The Japanese Society of Toxicologic Pathology
Previous article Next article
feedback
Top