Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
Case Report
Spontaneous malignant myoid thymoma in an aged female Fischer 344 rat
Yoshitaka KatohTsuyoshi ItoYuko ShimadaAya Ohnuma-KoyamaNaofumi TakahashiYoshimasa OkazakiAtsushi ShigaMaki KuwaharaToshinori YoshidaTakanori Harada
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2018 Volume 31 Issue 2 Pages 135-139


A whitish mass approximately 30 mm in diameter was noted in the anterior mediastinum of a 67-week-old female Fischer 344 rat. Histopathologically, two types of tumor cells were identified on the basis of morphologic features: epithelial tumor cells with a tubular or cord-like growth pattern and rhabdomyosarcomatous tumor cells characterized by the presence of cross-striations. Immunohistochemically, the epithelial tumor cells reacted positively for cytokeratin AE1/AE3, and some reacted positively for p63, which is expressed in normal thymic epithelial cells. The rhabdomyosarcomatous tumor cells stained positively for desmin, sarcomeric actin, and S-100 protein, which coincides with the stainability of normal thymic myoid cells. Since the tumor was also found to have malignant features such as high proliferative activity, cytologic atypia, and necrotic behavior, it was diagnosed as a malignant myoid thymoma. We believe that this is the first case report of such a tumor in a rodent.

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© 2018 The Japanese Society of Toxicologic Pathology
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