Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
Review
Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System
Annamaria Brändli-BaioccoEmmanuelle BalmeMarc BruderSundeep ChandraJuergen HellmannMark J. HoenerhoffTakahito KambaraChristian LandesBarbara LenzMark MenseSusanne RittinghausenHiroshi SatohFrédéric SchorschFrank SeeligerTakuji TanakaMinoru TsuchitaniZbigniew WojcinskiThomas J. Rosol
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2018 Volume 31 Issue 3_Suppl Pages 1S-95S

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Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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© 2018 The Japanese Society of Toxicologic Pathology
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