Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Original Article
Pathological study of tubular aggregates occurring spontaneously in the skeletal muscles of non-obese diabetic/Cg-PrkdcscidIl2rgtm1sug/ShiJic (NOG) mice
Saori IguraMariko NagataniKenichiro KasaharaRie AndohYachiyo FukunagaOsamu HashiguchiShuzo OkazakiYuko Yamaguchi
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2020 Volume 33 Issue 2 Pages 115-119


To examine the biological and morphological features of tubular aggregates (TAs) in the skeletal muscles of non-obese diabetic/Cg-PrkdcscidIl2rgtm1Sug/ShiJic (NOG) mice, 73 male and 72 female specific-pathogen-free NOG mice were examined at 7, 18, 22, 26, and 52 weeks of age. TAs were observed as intracytoplasmic eosinophilic materials of the femoral muscles in males at 18, 22, 26, and 52 weeks of age and in females at 52 weeks of age; gender-related differences were noted in the onset time and lesion degree. Intracytoplasmic materials were positive for Gomori’s trichrome stain. Electron microscopy revealed that TAs were composed of an accumulation of dilated sarcoplasmic reticulum. In addition, TAs were observed in the femoral and gastrocnemius muscles, but not in the soleus and diaphragm muscles, suggesting that TAs are present in fast muscle fibers. The morphology of TAs and the type of myofibers involved, as well as the gender difference in NOG mice were essentially the same as those of TAs observed in C57BL/6J and MRL+/+ mice.

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© 2020 The Japanese Society of Toxicologic Pathology
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