Anemia and Liver Cell Necrosis in Beagle Dogs

Abstract

Liver cell necrosis was caused in beagle dogs, whose blood in amount of one to two percent of the bodyweight was removed almost everyday for 6 weeks and their hematocrit values were approximately 10% at necropsy time. When animals are in a severe anemic condition attributable to drug administration in toxicological studies, anemia should be considered as a causative factor of liver damage in addition to the possibility of the direct effect of chemicals on the liver.