Abstract
The effect of hypertriglyceridemia was examined on streptozotocin (STZ)-induced diabetic nephropathy in rats. After repeated intraperitoneal injection with Triton WR- 1339 (Triton) in STZ-diabetic rats, food and water consumption and urine volume were significantly decreased and albumin/globulin ratio lowered compared with non-injected Triton and STZ-diabetic rats. Between STZ-diabetic rats with Triton injection and those without, no significant difference was observed in the extent of mesangial matrix and PAS, type IV collagen, fibronectin, and laminin positive areas. The results suggested that the proliferation of mesangial cells might be inhibited by the high levels of low and very low density lipoproteins, and diabetic nephropathy was not affected by the inducing of hypertriglyceridemia.
