Abstract
Wistar-Furth-Osaka (WF/Osp) rat strain has been considered to induce spontaneous gastrocolonic adenocar-cinoma. ACI rats, fosterbred from WF/Osp also developed the same type of colon adenocarcinoma. The serum from colon cancer-carrying rats induced the same tumors in Wistar/Shionogi (Wistar/Shi) rat strain, and the serum of which also induced analogous tumors in ACI rat strain by intraperitoneal injection at newborn period.
Negative staining on solid-phase immune electron microscopy study revealed numerous particles in the tissue culture medium of transplantable gastric carcinoma. To bring to light the infectious cell line, susceptible to colon cancer inducing virus was the consequential element to analyze transmissible agents. Using monoclonal antibody against colon cancer inducing virus, IF studies were carried out on all organs, mainly the chest, abdominal, and urogenital organs of cancer carrying WF/Osp rat. We found that the NBT-II cell line originating from the urinary bladder cancer cell is susceptible to gastrocolonic cancer inducing virus.
