Spontaneous Tumors in p53-Deficient Mice

Masaaki Okada; Hitoshi Kimura; Ken-ichi Yoshijima; Tsuneo Koike; Tomoko Imaeda; Yutaka Tanikawa; Akihiro Shinoda; Takashi Nishio

doi:10.1293/tox.10.239

Masaaki Okada, Hitoshi Kimura, Ken-ichi Yoshijima, Tsuneo Koike, Tomoko Imaeda, Yutaka Tanikawa, Akihiro Shinoda, Takashi Nishio

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Keywords: Spontaneous tumor, p53-deficient mouse, Homozygote, Malignant lymphoma

JOURNAL FREE ACCESS

1997 Volume 10 Issue 4 Pages 239-242

DOI https://doi.org/10.1293/tox.10.239

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Abstract

The p53-deficient mice (Riken mice) were examined for tumors occurring spontaneously histopathologically and hematologically. Histopathologically, 87% of the males with tumors and 86% of the females with tumors had malignant lymphomas or lymphatic hyperplasia. It must be safe to say that more marked tendency to have spontaneous malignant lymphomas is seen in the p53-deficient mouse.

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