CARCINOGENICITY STUDY OF GLYCINE IN FISCHER 344 RATS

Abstract

The carcinogenicity of commercial glycine (GL) was assessed in groups of 50 male and 50 female F344 DuCrj rats by application in the drinking water at levels of 0. 2.5 or 5.0% for 108 wk. A dose-dependent reduction in the mean final body weights of rats was observed with GL, the incidences of necrosis in the renal papillae also being increased by the treatment. Thus while the controls were negative, necrosis was observed in 3 of 40 males and 10 of 31 females given 5.0% GL, and 2 of 45 males and 14 of 46 females receiving 2.5% GL. Incidences of urinary bladder papilloma were 2 in 31 females (6%) given 5.0% GL and 4 in 46 female (8%) given 2.5% GL. One renal cell tumor was noted in a male receiving 5.0% GL, but no precancerous renal cell lesions. One pelvic transitional cell carcinoma was also found in a control male.