Abstract
Hepatocyte-like cells were observed in the pancreas of two male and one female B6C3F, mic and one male BDF1 mouse. These cells appeared in the areas composed of atrophic pancreatic acinar cells and showed no specificity for appearance near the pancreatic islets as reported in rats and Syrian hamsters. This result suggested that there may be no influence of the islet cells in pathological development of pancreatic hepatocytes in mice. Since no relationship between the appearance of pancreatic hepatocytes and administration of chemicals was shown in these mice, spontaneous occurrence of these cells, probably by metaplasia of the regenerating cells after atrophy of the acinar cells in the exocrine pancreas, has been suggested.
