Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
DILATED CARDIOMYOPATHY IN A WISTAR RAT
Yoshimasa Okazaki, Junko Matsumoto, Osamu Katsuta, Minoru Tsuchitani
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Keywords: Dilated cardiomyopathy, Myocardial hypertrophy, Disruption of myofibrils, Rat
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1995 Volume 8 Issue 2 Pages 155-159

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Abstract

A 57-week-old male Wistar rat died one week before the end of a toxicity study. Necropsy revealed subcutaneous edema, hydrothorax, dilatation of all cardiac chambers, and congestion in several organs. Light and electron microscopic examinations revealed myocardial hypertrophy, degeneration, fibrosis, and disruption of myofibrils and variable sized mitochondria. The entity is concluded to be dilated cardiomyopathy.

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© The Japanese Society of Toxicologic Pathology
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