SPONTANEOUS GASTRIC CARCINOIDS IN AGED SPRAGUE-DAWLEY RATS

Ryo Fukuda; Zen-yo Tanakamaru; Yasufumi Sakura; Takashi Nonoyama

doi:10.1293/tox.9.293

Ryo Fukuda, Zen-yo Tanakamaru, Yasufumi Sakura, Takashi Nonoyama

Author information

Keywords: Gastric carcinoid, Rat, Spontaneous, Enterochromaffin-like (ECL) cell

JOURNAL FREE ACCESS

1996 Volume 9 Issue 3 Pages 293-296

DOI https://doi.org/10.1293/tox.9.293

Details

Abstract

Spontaneous gastric carcinoids were observed in a 104-week-old male and a 112-week-old female Crl: CD (SD) Br rat. The tumors showed intramucosal proliferation and gave positive results in argyrophilic reaction. Ultrastructurally, variable numbers of electron-dense or electron-opaque secretory granules were observed in the cytoplasm of the tumor cells. These tumors were considered to be of enterochromaffin- like (ECL) cell origin.

Corresponding author

Register with J-STAGE for free!