Abstract
Phospholipidosis-inducing effects of difluorobenzhydrylpiperadine (DFBP) on cultured rat per-itoneal macrophages were studied as compared with those of several amphiphilic drugs. At 24 hr of exposure to DFBP as well as other amphiphilic drugs, intracytoplasmic acid hematein-stained inclusion bodies were dose-dependently produced in macrophages. Electron microscopy showed lamellar inclusion bodies in macrophages exposed to DFBP. Effective concentrations for 30% positivity of treated cells were: 0.43μM/diethylamino-ethoxyhexestrol, 1.9 μM/perhexiline, 2.8μM/quinacrine, 4.3μM/DFBP, 11μM/chlorcyclizine, and 14 μM/ propranolol. Neither almitrine nor aspirin induced the cytoplasmic inclusion bodies.
