Abstract
During regulatory toxicity testing studies using rodents, test article is commonly administered admixed with powdered diet in order to ensure a stable plasma level. Circadian variation in feeding behaviour may results in alteration of exposure to test article.This poster reports characterisation of the circadian variation of food intake in rats maintained under typical toxicity laboratory husbandry conditions. The results are of particular use in interpreting data from investigations such as measurements of systemic exposure to test article, and helping determine the timing of such investigations during the working day.
