Abstract
Ginseng is the most commonly used herbal products in Korea. It has many pharmacological activities, but ginseng is not free from adverse effects, possibly through drug-drug interaction (DDI). Various studies reported that ginseng inhibits CYP450s. The objective of this study was to determine the effect of red ginseng (p. ginseng) extract on the toxicokinetic of deltamethrin in male Sprague Dawley adult rats. Deltamethrin (DLM) [(S)-a-cyano-3-phenoxybenzyl-(1R, cis)-2,2-dimethyl-3-(2,2-dibromovinyl)-cyclopropane-1-carboxylate] is the synthetic type II pyrethroid insecticide and it is one of potent neurotoxicants. The rats were orally administered the red ginseng extract at 0, 10, 100 mg/kg for 2 weeks, followed by oral administration of DLM at 10 mg/kg in glycerol formal. Toxicokinetic parameters of DLM in plasma were not significantly changed by treatment of red ginseng extract. The present results indicated that red ginseng extract has no significant effect on toxicokinetics of DLM.
