Abstract
We have developed the screening test for drug and chemical compound of food by the use of rat whole embryo culture.
The advantages of whole embryo culture are to examine the direct effects of the ARB on rat embryo.
As the testing agent, ARB was examined in this study using the rat embryo cultured from day 11 to 13 gestation.
In this whole embryo culture system,rat embryos were explanted on day 11(plug day = 0) of gestation and cultured of rat serum with 95% O2 and 5%CO2 using improved rotator for 48hrs.
The group of treated embryos of ARB were not exchanged in the heart beat, the crown-rump length, the embryo weight and the embryonic total somite.
On the other hand, the malformation was not observed in the embryos cultured with ARB. The blood circuration of yolk-sac or embryo was increased the control group.
