Abstract
Deoxycorticosterone acetate salt hypertension (DSH) model is commonly used for investigating hypertension-associated renal fibrosis. Sesame oil is a natural product with potent anti-fibrosis property. We investigate the protective effect of sesame oil on deoxycorticosterone acetate salt-induced kidney damage in rats. Chronic renal injury in uninephrectomized rats was induced by deoxycorticosterone acetate and salty drinking water. After 4 weeks, rats were ingested with sesame oil (0.5 or 1 ml/kg) for 7 days. Renal injury, histopathological examination, collagen levels and osteopontin expression were assessed 24 h after the last dose of sesame oil. Serum blood urea nitrogen, creatinine levels as well as urine volume were significantly increased in DSH rats. Sesame oil significantly decreased all these parameters compared with them in DSH rats. Sesame oil significantly increased creatinine clearance rate in DSH rats. Further, sesame oil significantly decreased DSH-induced renal collagen and osteopontin over-expressions. Therefore, we summarize that sesame oil ameliorates chronic renal fibrosis through inhibiting renal osteopontin expression in DSH rats.
Keywords: deoxycorticosterone acetate salt hypertension (DHS), mineralocorticoid, chronic renal fibrosis, sesame oil, osteopontin, rat
