Molecular mechanisms and pathological consequences of the pro-senescence effects of trans-fatty acids

Abstract

trans-Fatty acids (TFAs), such as elaidic acid (EA), highly contained in processed foods, have been associated with a variety of age-related diseases including atherosclerosis and NASH. However, the underlying pathological mechanism remains unknown.

Here, we show that EA promoted DNA damage-induced cellular senescence and cytokine production (so called SASP) in a manner dependent on p53. Moreover, dietary intake of TFA induced accumulation of fat and senescent cells in mouse liver. In this meeting, we discuss the novel mechanisms underlying pro-senescence/inflammatory effects of TFAs.