Developmental immunotoxicity test of dinotefuran administered to mice in drinking water

Abstract

Dinotefuran has been shown to be transferred to offspring via the placenta or milk, which raises concerns about transgenerational effects. Here, ICR mice were given 0, 0.02 and 0.2% of dinotefuran diluted in water from GD 0 to PND 50, and the dams and their offspring were evaluated, focusing on the immunotoxicity. Some dosed groups showed a slight decrease of the WBC in maternal blood, and a tendency of increase of the proportion of Gr-1⁺ cells in the bone marrows of the mothers and the offspring. No statistically significant changes were observed in all of the parameters.