Structure-activity relationships for a zinc complex that exhibits cytotoxicity in vascular endothelial cells

Abstract

In the present study, we found that a zinc complex bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridiolato)zinc(II), named Zn-06, exhibited strong cytotoxicity in vascular endothelial cells. The characteristics of the structure was investigated, and the results showed that the tetracoordinate structure of the Zn-06 molecule, which contains two sulfur and two oxygen atoms coordinated with the zinc atom, facilitated its accumulation within vascular endothelial cells and the whole structure of the zinc complex was involved in its cytotoxicity in the cells. (J. Toxicol. Sci., 44(2):113-120, 2019)