Possibility of drug-drug interactions resulted from enzyme inhibition of Juzen-taiho-to in dogs

Abstract

Because Juzen-taiho-to may be administered for long-term due to characteristic of a traditional Chinese medicine and be used with other medicines, drug-drug interactions should be considered. In this study, drug-drug interactions resulted from enzyme inhibition of Juzen-taiho-to in dog liver microsomal cytochrome P-450 (CYP) were examined. Juzen-taiho-to most likely inhibited CYP 1A activity in major CYPs assessed in this study such as CYP 1A, 2D and 3A. However, it is hardly considered Juzen-taiho-to cause drug-drug interactions even on CYP 1A considering digestion and absorption.