The effects of CYP inhibitors and inducers on pharmacokinetics and toxicity of substance responsible for “Gin-nan food poisoning”（4′-O-Methylpyridoxine : MPN）

Abstract

We have previously reported that formation of pyridoxal (PL) from MPN by CYP1A2, was the rate-limiting step in a major metabolic pathway of MPN in mice. In this study, the effects of CYP1A inhibitors and inducers on convulsion which was a main symptom of “Gin-nan food poisoning” and on MPN and its metabolite concentrations in plasma and urine in mice were investigated. Treatment of mice with the inhibitor resulted in a increase in frequency of convulsion and in AUC of MPN, but in a decrease in AUC of PNA which was a further metabolite of PL. In contrast, treatment of mice with the inducers produced the opposite results of inhibitors.