Gene expression changes of epigenetic-related genes and spermatogenesis-related gene in the testes of F1 male mice gestationally exposed to arsenic

Abstract

In this study, to elucidate the effects of gestational arsenic exposure on the F1 reproductive system, we examined gene expression of epigenetic-related genes and spermatogenesis-related gene in F1 male mice gestationally exposed to arsenic. We found that gestational arsenic exposure probably induced DNA hypermethylation in the testis of F1 mice. Our results suggested that altered DNA methylation affected spermatogenesis through disruption of spermatogonia differentiation in the testis of gestationally arsenic exposed F1 mice.