Development of transcriptomic maps of preclinical species for assessment of target expression and distribution

Abstract

The goal of this project was to use RNA-Seq to profile a broad collection of tissues from preclinical species to build a comprehensive tissue expression atlas complementary to human tissue transcriptomic maps for rapid assessment of target distribution. Tissues from the same organ systems clustered together and overall human to nonclinical species correlation was above 60%. These datasets can also complement other information such as functional assay data to support the selection of pharmacologically relevant species for safety evaluation and de-risking studies of new drugs.