Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
Diabetes mellitus (DM), a common metabolic disorder, has increasingly raised great global health concerns. The complications of DM severely cost the finances of individuals and nations’ economies. Diabetic nephropathy is one of the most common long-term complications in patients with DM, in which microvascular changes often aggravate the illness and lead to chronic kidney disease. Extracts of Sigesbeckia Orientalis have been identified to have the excellent anti-oxidative activity and used in modern traditional Chinese medicine. In consideration of only few studies examining their effects on diabetic kidney, this study aims to explore the protective effects of the extracts on diabetic nephropathy and their underlying molecular mechanisms. Murine animals were first injected with streptozotocin (STZ) to induce diabetes mellitus, followed by orally given with the extracts for a 3-week treatment. After the treatment, the histological and morphometric analysis of animals in each group was performed. The results of our study provided the protective evidence of the extracts from Sigesbeckia Orientalis on diabetic nephropathy, with respect to the histological demonstration and immunohistochemistry staining for the expression patterns of 8-hydroxyguanosine (8-OHdG), relative proteins involved in nuclear factor kappa B (NF-κB) inflammatory pathway and endothelial nitric oxide synthase (eNOS) simultaneously.
