Application of read-across in screening assessment of general chemicals : A case of Nonan-1-ol (C₉H₂₀O)

Abstract

In a screening assessment under the Japanese Chemical Substances Control Law, the toxicity of nonan-1-ol (C₉H₂₀O; C9) has not been evaluated due to lack of data. In this study, we assessed the toxicity of C9 by read-across using the data of analogous substances. The ranges of NOAELs for repeated dose toxicity and reproductive/developmental toxicity were 370-2000 mg/kg/day and 130-2000 mg/kg/day, respectively. Results of all genotoxicity tests for the analogue substances were negative. Based on these results, hazard classes of the repeated dose toxicity and the genotoxicity of C9 were evaluated as “not classified”, and the reproductive/developmental toxicity was classified into “class 4”.