老齢ラット黒質AMPA受容体活性化は細胞内Zn2+毒性によるパーキンソン症候群を悪化させる

片平 実沙; 佐伯 奈々; 西尾 隆佑; 竹内 梓紗; 森岡 洋貴; 玉野 春南; 武田 厚司

doi:10.14869/toxpt.47.1.0_P-26S

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-26S

DOI https://doi.org/10.14869/toxpt.47.1.0_P-26S

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

AMPA receptor activation in the substantia nigra aggravates Parkinson's syndrome in aged rats via nigral intracellular Zn2+ dysregulation

*Misa KATAHIRA, Nana SAEKI, Ryusuke NISHIO, Azusa TAKEUCHI, Hiroki MORIOKA, Haruna TAMANO, Atsushi TAKEDA

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Abstract

We tested whether AMPA receptor activation in the substantia nigra causes Parkinson’s syndrome in rats. AMPA injection into the substantia nigra induced movement disorder and nigral dopaminergic neurodegeneration. AMPA-induced increase in nigral intracellular Zn²⁺ and AMPA-induced nigral neurodegeneration, which were accelerated with aging, were suppressed by co-injection of intracellular Zn²⁺ chelators. The present data suggest that AMPA receptor activation in the substantia nigra aggravates Parkinson’s syndrome in aged rats via nigral intracellular Zn²⁺ dysregulation.

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