Effects of airborne particle exposure on the prognosis of experimental ischemic stroke

Abstract

The purpose of this study is to investigate whether airborne particle exposure affects the prognosis of ischemic stroke.

Mice were intranasally administered airborne particles for 7 days and then subjected to focal cerebral ischemia by photothrombosis (PT). In airborne particle treated mice, Rotarod score as well as Hanging-wire and mNSS scores deteriorated, indicating decreased motor ability. Furthermore, mortality after PT increased by airborne particle exposure.

We have demonstrated for the first time that airborne particle exposure aggravates the outcome of ischemic stroke.