化学物質によるPXR活性化のマウス肝発がんへの影響解析

志津 怜太; 石村 麻衣; 信澤 純人; 保坂 卓臣; 佐々木 崇光; 柿崎 暁; 吉成 浩一

doi:10.14869/toxpt.47.1.0_P-43E

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-43E

DOI https://doi.org/10.14869/toxpt.47.1.0_P-43E

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

The influence of PXR activation on liver carcinogenesis in mice

*Ryota SHIZU, Mai ISHIMURA, Sumihito NOBUSAWA, Takuomi HOSAKA, Takamitsu SASAKI, Satoru KAKIZAKI, Kouichi YOSHINARI

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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

CAR and PXR are nuclear receptors highly expressed in the liver and activated by numerous chemicals. CAR activation by its activators such as phenobarbital induces hepatocyte proliferation and liver carcinogenesis in rodents. In contrast, it has been unknown whether PXR activation promotes liver carcinogenesis. In this study, to investigate the influence of PXR activation on liver carcinogenesis, we treated mice with the PXR activator PCN following the tumor initiator diethyl nitrosamine for 35 weeks. We have found that PXR activation didn't promote liver cancer in mice.

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