2型糖尿病モデルdb/dbおよびKK-Ayマウスの腎臓における高脂肪食摂餌の影響

山口 彩音; 美谷島 克宏; 宇野 絹子; 杉本 実紀; 黒木 楓子; 西田 芽衣; 小郷 智記; 煙山 紀子; 篠原 雅巳; 中江 大; 太田 毅

doi:10.14869/toxpt.47.1.0_P-45S

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-45S

DOI https://doi.org/10.14869/toxpt.47.1.0_P-45S

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Effect of high fat diet on kidney in db/db and KK-Ay mice

*Ayane YAMAGUCHI, Katsuhiro MIYAJIMA, Kinuko UNO, Miki SUGIMOTO, Fuko KUROKI, Mei NISHIDA, Tomoki OGOU, Noriko KEMURIYAMA, Masami SHINOHARA, Dai NAKAE, Takeshi OHTA

Author information

*Ayane YAMAGUCHI
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Katsuhiro MIYAJIMA
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Kinuko UNO
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture
Miki SUGIMOTO
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Fuko KUROKI
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Mei NISHIDA
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Tomoki OGOU
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Noriko KEMURIYAMA
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Masami SHINOHARA
Tokyo Animal & Diet Dept. CLEA Japan, Inc.
Dai NAKAE
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Takeshi OHTA
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

To investigate effects of high fat diet on kidney in obese type 2 diabetes model, 4-week-old male db/db and KK-Ay mice were fed CE-2 (BD: Basal Diet), Quick Fat (QF: High fat diet) or Western Diet (WD: QF+2% cholesterol added) ad libitum for 8 weeks. C57BL/6J mice were used as a control group. At 13 weeks of age, animals were dissected, collected the blood and organs and were performed various analysis.

In both diabetic strains, urinary protein content and fatty degeneration in the proximal tubular epithelium were prominent in the both fat diet groups as compared to BD and these changes were remarkable in KK-Ay mice. These enhancements were considered to relate to apparent insulin resistance in KK-Ay mice.

Corresponding author

Register with J-STAGE for free!