Ameliorating effect of α-glycosyl isoquercitrin on brain injury caused by LPS-induced developmental neuroinflammation in rats

Abstract

We examined the exposure effect of α-glycosyl isoquercitrin (AGIQ), an antioxidant, from developmental stage on neuroinflammation-induced brain injury produced by neonatal injection of lipopolysaccharide (LPS) in rats. LPS-injected animals revealed abnormal behaviors, increased oxidative stress in the brain, neuroinflammation and decreased mature granule cells in the dentate gyrus from early postnatal life. AGIQ exposure improved LPS-induced changes. Thus, AGIQ ameliorated the LPS-induced brain injury and abnormal behaviors by anti-inflammatory effects from early period of treatment.