Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
We aimed to elucidate the possible intervention of inorganic arsenic compounds (AS) exposure with allergic asthma development. A mouse model of asthma was developed by intranasal administration of mite extract (ITEA Inc). AS (10 and 100 ppm) were orally administered in drinking water during the experimental period. Eosinophils, cytokine levels, IgE-positive B cells and serum IgE level were analyzed. AS exposure significantly heightened the number of eosinophils, cytokine levels, number of IgE-positive B cells and serum IgE levels compared to the control group. Our findings imply that AS exposure exacerbated the response in a mouse model of allergic asthma.
