Individual variations in expression of genes related to airway hyperresponsiveness in human trachea and lung

Abstract

Significant individual differences have been noted in the degree of onset and symptoms of sick house syndrome, but the mechanism has not been elucidated. In this study, to this end, we evaluated the expression levels of ADAM33 and other genes in human tracheal and lung tissues, which are known to be involved in airway hyperreactivity and asthma. Real-time RT-PCR revealed that the gene expression level of ADAM33 did not show significant individual differences in trachea. In contrast, the levels of MMP9 and GPR99 (OXGR1) showed remarkable individual differences in trachea and lung. It is possible that these factors play an important role as one of the factors explaining individual differences in the degree of onset of sick house syndrome.