Annual Meeting of the Japanese Society of Toxicology
The 47th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-8E
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Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster
Mechanism involved in the induction of OSM expression by methylmercury in microglia
*Takayuki HOSHI, Takashi TOYAMA, Akira NAGANUMA, Yoshiro SAITO, Gi-Wook HWANG
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Abstract

In this study, we aimed to elucidate the mechanism involved in the induction of oncostatin M (OSM) by methylmercury in microglia. We found that methylmercury induced OSM expression by activation of STAT3 and cJun, which are subunit of known transcription factors for OSM expression, in mouse microglial cell line BV2. Moreover, knockdown of up-stream kinases (JAK1 or ASK1/JNK) for STAT3 or cJun also attenuated methylmercury-induced OSM expression. These results suggest that methylmercury may induce OSM expression via JAK1/STAT3 and ASK1/JNK/cJun pathways in microglia.

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