糖尿病モデル動物であるSDT fattyラットにおけるCDAA食ならびにHF食の肝臓及び脂肪組織に及ぼす影響

万代 康平; 美谷島 克宏; 山口 彩音; 山本 敦也; 町田 七海; 森田 茉穂; 岩本 健志郎; 煙山 紀子; 篠原 雅巳; 太田 毅; 中江 大

doi:10.14869/toxpt.47.1.0_P-93S

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-93S

DOI https://doi.org/10.14869/toxpt.47.1.0_P-93S

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Investigation of CDAA and HF diet on liver and adipose tissue in SDT fatty rats, obese type 2 dibetic animals

*Kouhei MANDAI, Katsuhiro MIYAJIMA, Ayane YAMAGUCHI, Atsuya YAMAMOTO, Nanami MACHIDA, Maho MORITA, Kenshiro IWAMOTO, Noriko KEMURIYAMA, Masami SHINOHARA, Takeshi OHTA, Dai NAKAE

Author information

*Kouhei MANDAI
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Katsuhiro MIYAJIMA
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Ayane YAMAGUCHI
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Atsuya YAMAMOTO
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Nanami MACHIDA
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Maho MORITA
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Kenshiro IWAMOTO
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Noriko KEMURIYAMA
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
Masami SHINOHARA
Tokyo Animal & Diet Dept. CLEA Japan, Inc.
Takeshi OHTA
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Dai NAKAE
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture

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Abstract

To investigate the effects of choline-deficient methionine-lowered amino acid diet (CDAA) or high fat diet (HF) on SDT fatty (f) rats, which are obese type 2 diabetic animals, on liver and intraperitoneal adipose tissue, 17 weeks old male SDT f and SD rats were fed basal diet (CE2), HF or CDAA ad libitum for 4 weeks. At 21 weeks of age, animals were dissected, collected the blood and organs and were performed various analysis.

In SDT f rats, the induction of fatty liver by CDAA or HF were weaker than those in SD rats, on the other hand, the visceral fat accumulation by HF was more apparent. The mechanism of these changes will be analyzed.

Corresponding author

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