Suppressive mechanism of cold compress on cytotoxicity induced by mitomycin C

Abstract

In this study, we examined the inhibitory effect of cold compress on cytotoxicity of MMC using apoptosis and oxidative stress as an indicator.

In the cells exposed to MMC at 37°C, that caused apoptosis significantly increased from 24 hours after exposure. On the other hand, cells exposed to MMC at 23°C did not caused apoptosis. Only cells exposed to MMC at 37°C, the intracellular malondialdehyde concentration significantly increased.

Therefore, apoptosis and oxidative stress were observed in the cytotoxicity caused by MMC, and it was clarified that the cold compress suppressed these.