Neurobehavioral toxicity of adult male mice induced by disturbance of neuronal signals at developmental period～The mouse model of brain disease by marine poison part2～

Abstract

Domoic acid (DA) is a kainic acid-type neurotoxin that causes amnesic shellfish poisoning. Previously, we demonstrated brain dysfunction with behavioral impairments by the disturbance of neural signals at prenatal period by using DA. In this symposium, we will show the effects on emotional/cognitive behavior of male adult mice induced by administration of DA at postnatal period. Furthermore, we also introduce the experimental trials to develop countermeasures against DA poisoning.