Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
Cyanotoxin microcystin-LR (MC-LR) induces acute injury of hepatocytes through protein phosphatases PP1/PP2A inhibition. In case of its chronic exposure, MC-LR induces hepato-carcinoma caused by acceleration of cell proliferation. Previously, we demonstrated the molecular basis for hepato-selective cytotoxicity of MC-LR which is taken-up into cells mediated by hepatocyte-specifically expressing transporter OATP1B1/1B3. Recently, we demonstrated a novel function of MC-LR which induced bi-potentially changes including anoikis resistance and cytoskeleton reorganization. In this symposium, I will discuss about association with epithelial-mesenchymal transition of these cells.
