Annual Meeting of the Japanese Society of Toxicology
The 47th Annual Meeting of the Japanese Society of Toxicology
Session ID : S13-2
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Symposium 13
Approach of reduction in drug discovery research
*Toshihiko WATANABE
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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Reduction, which is one of 3R's, often appears as a result of Replacement or Refinement, and it is difficult to discuss the very idea of Reduction.

The technology of compound synthesis progressed significantly, a vast number of compounds came to be synthesized in pharmaceutical industry. However, the number of animals used has not increased significantly in proportion to the increase in synthetic numbers.

In this symposium, this fact will be re-evaluated and considered to build a function of promote 3R’s “Reduction”. We would consider what is necessary to promote the 3R's in the following points.

1) We reconfirm that it is contributing to the 3R's without knowing it, when look back at the process of drug discovery research from the viewpoint of animal welfare.

2) We understand the 3R's award and 3R's day initiatives in Europe and consider what drives 3R's research.

3) We find research in the development of in vitro technology that could contribute to 3R's in the future, and boost it from the viewpoint of animal welfare.

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© 2020 The Japanese Society of Toxicology
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