Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
By mass, the cerebellum constitutes about only 10% of the total volume of the central nervous system. However, the number of cerebellar granule cells comprises 60-80% of the total neurons in the central nervous system. During normal development, a massive number of granule cells are generated from granule cell precursors, which is elicited through various intracellular and extracellular signaling cascades. Drug exposure to developing individuals occasionally results in maldevelopment of granule cells. I this talk, I introduce our recent findings on the molecular machinery for granule cell development and discuss the possibility that mouse granule cell development can be used as the in vivo evaluation system for drug exposure.
