Prediction of drug-induced liver injury (DILI) using in vitro evaluation systems at early preclinical stage in drug development

Abstract

In this presentation, our approaches to establish in vitro evaluation systems for predicting DILI at early preclinical stage are introduced. To predict intrinsic or idiosyncratic DILI, we show what types of data are collected and referenced. Logically, in the vitro evaluation systems are only "predictive" of in vivo or human DILI, and "validation" step would be essential when "prediction" is made. Our current challenge is to establish not only in vitro evaluation systems but also in silico models for DILI prediction.