The mechanism of methylmercury-induced peripheral neurotoxicity in rat

Abstract

Methylmercury (MeHg) is known to cause central/peripheral nerve disorders. To elucidate the mechanism of the peripheral neurotoxicity to MeHg, we performed the behavioral analysis, genetic and immunohistochemical analysis of the dorsal root ganglion (DRG). In the MeHg exposed rat, each sensory modality responded in different timings. Microarray data showed that TNF-α and TLR pathways were involved. Moreover, the activation of microglia/macrophage in DRG was observed. These data suggest that MeHg-induced neurotoxicity in peripheral nerve may occur via inflammatory responses.